Variant BA.5 Covid: France, symptoms, duration, infection

BA.5, a sub-variable of the Omicron variant, predominates in France but its circulation decreases in August. Clinical signs include fatigue, vomiting, and sore throat. Tags can be up to 7 days long. Symptoms, duration, infection, treatments… All about the COVID-19 variant BA.5

The initial virus of Covid-19, Sars-Cov-2, has mutated several times to a variant Omicron Which began to arrive at the end of 2021 in France. Now everywhere, this variant has Five subspecies that Bachelor’s degree 5. The majority have been in France for several weeks, France Public Health reports In his last point. The symptoms The most common is Fatigue, cough, fever, headache, sore throat. Vomiting, diarrhea and night sweats equal mentioned. This BA5 variant is “Highly transmissible but no more dangerous” Called the head of the scientific council for Covid on July 11 in France Inter. people Positive and vaccinated should isolate themselves 7 days or 5 days in the case of a negative test on the fifth day and in the case of no symptoms for 48 hours on the fifth day.

What is a BA.5 variant?

BA.5 is a substrain of the Omicron variant of Covid-19. It began to be recognized in January and February 2022 in South Africa According to ECDC; Early April according to Public Health France. aired in Portugal, which led to a new wave of Covid-19 in May that was particularly virulent for those over their 80s. He’s being watched especially because he did it L452 . mutants (eg BA.4) associated with increased delta transmissibility.

What are the symptoms of the BA.5 variant?

According to Santé Publique France, the most common clinical signs in BA.4 and BA.5 variants are Fatigue, cough, fever, headache. In addition to, “Prospect present loss of smell [perte d’odorat] and age [perte du goût]but also nausea, vomiting and diarrhea higher For BA.4 / BA.5 issues” says the health agency. to meInstead of lasting 4 days on average, it lasts Instead of 7 days or even 10 days So we pollute longerDr. Demian Maskert explained on June 27. new symptoms Reported by Professor Luke O’Neill of Trinity College Dublin (Ireland): night sweats : “The disease is different because The virus has changed, Night sweats are a new symptomThe immunologist told Irish radio Newstalk on July 7.

Age and symptoms of BA.4 and BA.5 cases compared to BA.1 cases as of June 15 © Public Health France

How long do symptoms of the BA5 variant last?

The The average duration of clinical signs is 7 days For BA.4 and BA.5 cases versus 4 days for other OMICRON cases.

What is the price of a BA.5 variant in France?

Within the Omicron variant, the gradual replacement of the BA.2 sub-chain with Bachelor 5 Continue and become the last The majority in the French capital since June 13, 2022. BA.5 accounted for 92% of the screens analyzed By Public Health France in a flash survey on July 11 (compared to 3.6% for the BA.2 it replaced). As for BA.4, it was detected in 6.2% of the sequences.

Omicron variant sub-strings during flash polls in July 2022
Omicron variable sub-strings during flash polls July 18, 2022 © Public Health France

Is the BA.5 variant more contagious?

BA5 It is more contagious than BA2. Given the fact that it is more contagious, Escapes immunity after vaccination a little better So we’ll probably keep seeing this New cases will be renewed in the coming weeksYves Buisson, head of the Covid-19 cell of the Academy of Medicine in Europe, explained on June 7 Symptoms last longer (7-10 days)”So we pollute longerExplanation of Dr. Demian Maskart 27 June. The Omicron BA.4 and BA.5 subfonts replaced the BA.2 fonts and resulted in A new epidemic wave in South Africa (5th wave). Same for BA.5 exclusively to Portugal (With a greater epidemiological impact on those over the 80s.)

In South Africa : The BA.4 growth rate is +8% per day compared to BA2; +12% for Bachelor’s degree 5.

To Portugal:BA.5 has been associated with the resumption of the epidemic but the peak of this wave that started at the end of April appears to be now gone. If confirmed, the amplitude of the wave will be much less than the previous one.The French public health authority reported on June 15.

Is the BA.5 variant more dangerous?

Data is accumulated in several countries No increase in severity associated with BA.4 and BA.5 . was observed. A first study from South Africa comparing the risk of serious events between Omicron wave BA.1 and wave BA.4/BA.5 demonstrated Omicron wave BA.5 Similar risks of hospitalization or death between waves BA.1 and BA.4/BA.5, Public Health France reports 6 July. These two waves are associated with an omicron Less risks compared to previous waves. The risk of hospitalization/death was Less in previously infected cases (70% less) or Vaccine 3 doses (83% lower) compared to uninfected/vaccinated cases. “Average length of hospitalization (for BA4 or BA5 cases, editor’s note) is 5 daysPublic Health France indicated on June 15.

Are vaccines effective against the BA.5 variant?

Preliminary data found only from UK There is no significant difference in the effectiveness of the vaccine for BA.4 and BA.5 compared to BA.2, according to Santé Publique France in its July 6 variable risk analysis. An analysis of wave BA.4/BA.5 in South Africa noted that the rate of hospitalization is similar to wave BA.1. “This data supports a Vaccine efficacy and severity similar to BA.4 and BA.5 Compared to previous Omicron sublines” France Public Health Estimates.

What treatments are effective if I have the BA.5 variant?

The Baxlovid Therapeutic treatment remains first-line regardless of the SARS-CoV2 variant or sub variant. “Its activity was not modified against BA.4 and BA.5 compared to the BA.1 and BA.2 subvariables.” The Directorate General of Health confirms on July 11. This antiviral is given orally. It can be prescribed by any doctor, and is available in health institutions and community pharmacies since February 2, 2022. If there are contraindications to the use of Baxlovid (especially with regard to drug interactions), treatment Evoshield (tixagevimab 150 mg / cilgavimab 150 mg) is available. It is administered in healthcare facilities by intramuscular injection.

What are the differences between the BA.5 variant and the BA.2 variant?

BA.4 and BA.5 spread better than BA.2. This one (BA5, editor’s note) It survives the vaccine a little better. It shows the evolutionary ability of a virus capable of evading vaccines, at the same time increasing its transmission. But we know that too Symptoms are not more severeEpidemiologist Anne-Claude Crémieux said June 22 on FranceInfo. “These two subspecies are Very similar to BA.2 But the spike protein also has mutations L452R/ F486V and refer R493Q. BA.4 and BA.5 soon replaced BA.2 in South Africa. Bachelor 4 and Bachelor 5“French public health reported on May 18. The boom L452R, also found in the delta variant, continues to increase positive Covid tests in France. L ‘mid-age Cases investigated in France 47 years, higher than the incidence of BA.1 (35 years).

Sources:

A risk analysis for emerging variants of SARS-CoV-2 was carried out jointly with Public Health France and the CNR for Respiratory Infection Viruses, 6 July 2022.

– A risk analysis of emerging variants of SARS-CoV-2 was carried out jointly with Public Health France and the CNR for Respiratory Infection Viruses, 15 June 2022.

– Epidemiological update: SARS-CoV-2 Omicron sublines BA.4 and BA.5, ECDC, May 13, 2022

– Epidemiological Bulletin, Public Health France

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