Variant BA.5 Covid: Symptoms, Infection, Effective Vaccines?

A new COVID variant. BA.5, a sub variant of Omicron, is the majority in France. Fatigue and a sore throat are the most common symptoms. Very preliminary data support a vaccine efficacy similar to other Omicron strains.

[Mise à jour le 11 juillet 2022 à 12h37] The initial virus of Covid-19, Sars-Cov-2, has mutated several times to a variant Omicron Which began to arrive at the end of 2021 in France. Now everywhere, this variant has Five subspecies that BA.5 which is now the majority in France But also in most European countries where it has replaced the BA.2 variant. “The preliminary data available today supports a Vaccine efficacy and one similar intensity of BA.5 compared to other Omicron sublines” informs Public Health France in its latest risk analysis on variants which was published on July 6, 2022.”Since it is a new variant, it knows fewer people He is more active Dr. Charles Henry Guise, GP and Vice President of the Union of Liberal Physicians (URPS) explained on BFM-TV on July 4. Once we get to know it a little better, its intensity will decrease. We mainly see Cold symptomswith temperaturea a headache (…) The patients very tired.”

What is a BA.5 variant?

BA.5 is a substrain of the Omicron variant of Covid-19. It began to be recognized in January and February 2022 in South Africa According to ECDC; Early April according to Public Health France. aired in Portugal, which led to a new wave of Covid-19 in May that was particularly virulent for those over their 80s. He’s being watched especially because he did it L452 . mutants (eg BA.4) associated with increased delta transmissibility.

What are the symptoms of the BA.5 variant?

According to Santé Publique France, the most common clinical signs in BA.4 and BA.5 variants are Fatigue, cough, fever, headache. In addition to, “Prospect present loss of smell [perte d’odorat] and age [perte du goût]but also nausea, vomiting and diarrhea higher For BA.4 / BA.5 issues” says the health agency. to meInstead of lasting 4 days on average, it lasts Instead of 7 days or even 10 days So we pollute longerExplanation of Dr. Demian Maskart 27 June.

Age and symptoms of BA.4 and BA.5 cases compared to BA.1 cases as of June 15 © Public Health France

How long do symptoms of the BA5 variant last?

The The average duration of clinical signs is 7 days For BA.4 and BA.5 cases versus 4 days for other OMICRON cases.

What is the price of a BA.5 variant in France?

Within the Omicron variant, the gradual replacement of the BA.2 sub-chain with Bachelor 5 Continue and become the last Majority in urban France since the rapid survey on June 13, 2022. BA.5 captured 67% of the explainable snapshots in the June 20 Flash Poll. In most European countries, BA.5 has also become the majority.

Omicron variant sub-strings during flash polls in July 2022
Omicron variant sub-strings during flash polls July 4, 2022 © Public Health France

Is the BA.5 variant more contagious?

BA5 It is more contagious than BA2. Given the fact that it is more contagious, Escapes immunity after vaccination a little better So we’ll probably keep seeing this New cases will be renewed in the coming weeksYves Buisson, head of the Covid-19 cell of the Academy of Medicine of Europe, explained on June 7 Symptoms last longer (7-10 days)”So we pollute longerExplanation of Dr. Demian Maskart 27 June. Omicron sublines BA.4 and BA.5 replaced BA.2 and resulted in A new epidemic wave in South Africa (5th wave). Same for BA.5 exclusively to Portugal (With a greater epidemiological impact on those over the 80s.)

In South Africa : The BA.4 growth rate is +8% per day compared to BA2; +12% for Bachelor’s degree 5.

To Portugal:BA.5 has been associated with the resumption of the epidemic but the peak of this wave that started at the end of April appears to be now gone. If confirmed, the amplitude of the wave will be much less than the previous one.The French public health authority reported on June 15.

Is the BA.5 variant more dangerous?

Data is accumulated in several countries No increase in severity associated with BA.4 and BA.5 . was observed. A first study from South Africa comparing the risk of serious events between Omicron wave BA.1 and wave BA.4/BA.5 demonstrated Omicron wave BA.5 Similar risks of hospitalization or death between waves BA.1 and BA.4/BA.5, Public Health France reports 6 July. These two waves are associated with an omicron Less risks compared to previous waves. The risk of hospitalization/death was Less in previously infected cases (70% less) or Vaccine 3 doses (83% lower) compared to uninfected/vaccinated cases. “Average length of hospitalization (for BA4 or BA5 cases, editor’s note) is 5 daysPublic Health France indicated on June 15.

Are vaccines effective against the BA.5 variant?

Preliminary data found only from UK There is no significant difference in the effectiveness of the vaccine for BA.4 and BA.5 compared to BA.2, according to Santé Publique France in its July 6 variable risk analysis. An analysis of wave BA.4/BA.5 in South Africa noted that the rate of hospitalization is similar to wave BA.1. “This data supports a Vaccine efficacy and severity similar to BA.4 and BA.5 Compared to previous Omicron sublines” France Public Health Estimates.

What are the differences between the BA.5 variant and the BA.2 variant?

BA.4 and BA.5 spread better than BA.2. This one (BA5, editor’s note) It survives the vaccine a little better. It shows the evolutionary ability of a virus that is able to evade vaccines, while increasing its transmission. But we know that too Symptoms are not more severeEpidemiologist Anne-Claude Crémieux said June 22 on FranceInfo. “These two subspecies are Very similar to BA.2 But the spike protein also has mutations L452R/ F486V and refer R493Q. BA.4 and BA.5 soon replaced BA.2 in South Africa. Bachelor 4 and Bachelor 5“French public health reported on May 18. The boom L452R, also found in the delta variant, continues to increase positive Covid tests in France. L ‘mid-age Cases investigated in France 47 years, higher than the incidence of BA.1 (35 years).

Sources:

A risk analysis for emerging variants of SARS-CoV-2 was carried out jointly with Public Health France and the CNR for Respiratory Infection Viruses, 6 July 2022.

– A risk analysis of emerging variants of SARS-CoV-2 was carried out jointly with Public Health France and the CNR for Respiratory Infection Viruses, 15 June 2022.

– Epidemiological update: SARS-CoV-2 Omicron sublines BA.4 and BA.5, ECDC, May 13, 2022

– Epidemiological Bulletin, Public Health in France

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